Endocrine Abstracts

Benign prostatic hyperplasia and prostate cancer are androgen-dependent diseases. Dihydrotestosterone (DHT) is a 5α-reduced metabolite of testosterone (T), which is the causative factor for the progression of these diseases. The 5α-reductase enzyme (5α-R) converts T to DHT, which is responsible for increasing cell proliferation, and hence inhibition of this enzyme could lead to potential treatments for these afflictions. This study aimed to determine the biologi...

Prostate and seminal vesicles are male accessory sex glands secreting fluids that, together with sperm, form the semen. Clear evidence indicating these organs depend on androgens was found the men suffering hypogonadism because, in them, the function of these glands decreases markedly. Because prostate and seminal vesicles are androgen-dependent organs, they have been used as a model to test antiandrogenic drugs in different animal species.The objective ...